Research Groups

David Vermijlen Group

Description of the research topics

γδ T cells are unconventional T cells that express a γδ T cell receptor (TCR) on their cell surface instead of an αβ TCR as on conventional CD4+ and CD8+ αβ T cells. γδ T cells can have several roles, including protection against infections and tumors. The general approach of our current research is to obtain insight into human γδ T cells by applying sophisticated molecular biological techniques (such as TCR repertoire analysis) on clinical samples. Important in vivo findings are then further investigated in vitro in order to understand molecular mechanisms. In parallel, mouse models are used to address particular research questions. A main focus of our research is the role and ontogeny of γδ T cells in early life. Furthermore, recently γδ T cells have been in the spotlight of innovative anti-tumour therapies thanks to their unique features. Our group also investigate these cells in cancer context, usually in collaboration with other research teams.

Members

Principal Investigator

VERMIJLEN, David
PhD
After his PhD at the VUB on natural killer cells of the liver, David went to London for a post-doc in the laboratory of Prof. Adrian Hayday at King’s College to investigate human γδ T cells (2003-2006). After his return to Belgium, David continued to work on γδ T cells at the ULB, with a focus on their role and ontogeny in early life. He is associate professor at the Faculty of Pharmacy since 2012.
026505295

Postdoctoral Fellow

KÖHLER , Arnaud
PhD
Arnaud joined the lab in 2011 as a PhD student in Biomedical Science with a F.R.I.A. grant (team Véronique Flamand). He co-discovered the neonatal precursors of type 1 conventional dendritic cells. He developed a strong expertise on the impact of microbiota on neonatal pre-cDC1. He is now conducting preclinical research in the teams of Véronique Flamand and David Vermijlen on the cross-talk between maternal microenvironment and the neonatal pre-cDC1 and γδ T cells.
02/650.95.98
PAPADOPOULOU, Maria
PhD
Maria joined the lab in October 2015. She is a pharmacist and obtained a FRIA scholarship (FNRS) for her thesis entitled ‘Thymic development and peripheral functional polarisation of human Vγ9Vδ2 T cells’ (supervisor David Vermijlen). She currently continues to work on γδ T cells, including the investigation of their role in biliary atresia (a liver disease affecting young children) and placental malaria infection.
026509599

PhD Student

SANCHEZ, Guillem
MSc
Guillem obtained a Master in Advanced Immunology (University of Barcelona) and started as a PhD student in the team of David Vermijlen in October 2019. His primary research topic is the molecular understanding of the generation of human innate γδ T cells. He is investigating as well the role of γδ T cells in sepsis in infants and is involved, via external collaborations, in other projects such as the repertoire analysis of unconventional αβ T cells.
026509553
TAFESSE, Yohannes
MSc
Yohannes obtained his master's in Molecular Biology and Genetics from the University of Pavia. He joined the team of David Vermijlen in November 2019. In close collaboration with the team of Véronique Flamand, he is investigating the role of the (maternal) microbiome in the development and function of γδ T cells in an early-life mouse model, and whether this can be modulated by the maternal administration of probiotics.
026509553
VERDEBOUT, Isoline
MSc
Isoline obtained a Master in Pharmaceutical sciences from the ULB. She joined the team of David Vermijlen as a PhD student in October 2021. She is investigating the role of a common genetic variation on the development of innate versus adaptive γδ T cells and the potential underlying mechanisms.
026509553

Previous Lab Member

DIMOVA, Tanya
PhD
Tanya Dimova was a post-doctoral fellow in the team of David Vermijlen from 2009 till 2012 (funding FEDER/European commission, ‘Immunomonitoring of gammadelta T cells’). Her research focused on the gammadelta T cells present in human fetal peripheral blood.
GATTI, Deborah
PhD
Deborah was a post-doctoral fellow in the team of David Vermijlen from 2017 till 2019, with an MSCA individual fellowship (Horizon 2020, European Commission). She worked on γδ TCR ligand identification and participated to projects related to human γδ T cell development.
MA, Ling
PhD
Ling obtained her master from the Beijing University of Chinese Medicine. She joined the team of David Vermijlen in November 2015 and presented her PhD thesis in 2020, entitled: 'The γδ T cell response towards Toxoplasma infection and towards mistletoe extracts'.
TIEPPO, Paola
PhD
Paola joined the team of David Vermijlen in 2014. She defended with success her PhD thesis in 2020, entitled 'The development of human fetal γδ thymocytes'.
VAN HEDE, Dorien
PhD
Dorien performed her PhD thesis entitled ‘Role of γδ T cells in the progression of human papilloma virus-associated lesions’ (2012-2017), under co-supervision with Nathalie Jacobs (ULiège).