Description of the research topicsDespite many advances, infectious diseases remain the major causes of morbidity and mortality in much of the world. The goal of our research group is to improve our fine understanding of the factors that orchestrate antimicrobial host protective immune responses in vivo.
We are working on several different aspects at the interface between the host and Brucella, the bacteria responsible of brucellosis, a worldwide zoonosis. Our main objectives are:
(i) the development and characterization of new more physiological experimental models of Brucella infection in mice (such as intranasal and intradermal infection models)
(ii) the characterization of Brucella reservoir cells in vivo
(iii) the identification of immune effectors implicated in the control of primary and secondary infections
(iv) the identification by Transposon-sequencing of bacterial genes specifically required to escape the immune response
Our research works are interdisciplinary (immunology, microbiology) and involve a close cooperation between the Université Libre de Bruxelles (ULB) (animal facility, immunohistofluorescent microscopic analysis) and Université de Namur (UNamur) (flow cytometry analysis, Biosafety Level 3 laboratory).