Research Groups

Guillaume Oldenhove Group

Description of the research topics

The prevalence of obesity has increased dramatically over the past three decades and has contributed to the increasing prevalence of insulin resistance (IR) and type 2 diabetes (T2D) as well as cardiovascular disease, fatty liver/cirrhosis, hypertension, and cancer. Immune parameters are profoundly deregulated in obese individuals, creating a state of inflammation that affects the homeostasis of multiple tissues. Recent reports have clearly identified the type 2 axis as a major regulator of adiposity. We are particularly interested in the mechanisms that governs the function of several actors of the type 2 response as group 2 innate lymphoid cells (ILC2), Th2 and Treg. A better understanding of how adipose tissue type 2 lymphocytes are regulated may lead to design better vaccines and immuno-targeted therapies in the context of obesity.

Members

Principal Investigator

OLDENHOVE, Guillaume
PhD
After his PhD at ULB on the control of immune responses by regulatory T cells, Guillaume moved in 2007 as a visiting research fellow in the Laboratory of Parasitic Diseases at the National Institutes of Health (NIH), USA, to study the mechanisms that govern regulatory T cells plasticity. After his post-doc, he returns to ULB and focus his work on mechanisms controlling the development of inflammatory responses in tissues, with particular emphasis on the gastrointestinal tract and adipose tissue
02 650 98 64
Send an email

University Professor

MOSER, Muriel
PhD
Send an email

PhD Student

BIERLAIRE, Sébastien
PhD
Sebastien graduated from Veterinary Medicine in 2022. After working in a biopharmaceutical company, he joined the lab in September 2024 as a PhD student. His thesis focuses on innate lympoid and regulatory T cells in adipose tissue, and their role in inflammatory pathologies.
Send an email
ENGLEBERT, Kevin
MSc
Kevin joined the lab in 2016. He received a FRIA fellowship to study the mechanisms that regulate the immune response associated with adipose tissue. His work focuses on the role of negative costimulators that modulate type 2 immunity in the context of obesity.
Send an email

Technician

ACOLTY, Valérie
BSc
Valérie has a solid expertise in cell culture, immunoassays and Flow cytometry. She has a strong expertise in the field of vaccine immunity and preclinical mouse models.
02 650 98 64
Send an email

Administrative staff

DECOT, Isabelle
Isabelle provides administrative support to different team members of the laboratory.
02 650 98 61
Send an email