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When inflammation protects the gut

Tristetraprolin (TTP) is an RNA-binding protein that plays a major role in the control of inflammation. TTP KO mice spontaneously develop a complex multi-organ inflammatory syndrome but no overt intestinal inflammation, suggesting the involvement of local regulatory mechanisms. In this study published in the European J of Immunology and led by Bérengère de Toeuf and Maxime Melchior in the team of Stanislas Goriely, the researchers observed local expansion of IL-22-producing type 3 innate lymphoid cells (ILC3s) in the lamina propria of TTP KO mice. They show that these mice were paradoxically protected from Dextran Sulfate Sodium (DSS)-induced colitis, a finding related to increased IL-22 production by ILC3. Taken together, these data highlight the complex interplay between systemic inflammation and gut mucosal immune homeostasis.


April 02nd 2025 - 09:41