Description of the research topics
We are trying to understand how basic molecular mechanisms impact the differentiation and function of immune cells and how they can be exploited in the context of inflammation, infections or cancer.Research in our laboratory includes the following areas:
We are interested in the developmental plasticity of the mononuclear phagocyte system and the control of cytokine production in the context of infection, chronic inflammation and cancer. These projects focus on the role of epigenetic regulation and mRNA destabilization. They involve transcriptomic and epigenomic approaches, pre-clinical animal models, the development of a humanized mice platform and collaborations with clinicians. Recently, we also evaluate the impact of infections (such as SARS-Cov2) on innate immune cell function.
- Molecular mechanisms involved in the control of inflammation
We are interested in the developmental plasticity of the mononuclear phagocyte system and the control of cytokine production in the context of infection, chronic inflammation and cancer. These projects focus on the role of epigenetic regulation and mRNA destabilization. They involve transcriptomic and epigenomic approaches, pre-clinical animal models, the development of a humanized mice platform and collaborations with clinicians. Recently, we also evaluate the impact of infections (such as SARS-Cov2) on innate immune cell function.
- Transcriptional control of CD8 T cell differentiation