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Recent publication : Myeloid tumor necrosis factor and heme oxygenase-1 regulate the progression of colorectal liver metastases during hepatic ischemia-reperfusion

Liver ischemia/reperfusion occurring during surgical procedures such as partial hepatectomy contributes to colorectal liver metastasis progression. Desislava Germanova in the team of Véronique Flamand demonstrated that in this setting the tumor progression is occuring despite the local production of TNF by resident macrophages (Kupffer cells). She shows that the liver ischemia/reperfusion induced a Kupffer cell number decrease most likely through pyroptosis that favors the recruitment of TNF producing protective monocytes. However, the anti-tumoral capacity of these myeloid cells is dominantly limited by immunosuppressive factors including the heme-oxygenase 1 activity that is induced during the liver ischemia/reperfusion process.

Original publication : Desislava Germanova et al., "Myeloid tumor necrosis factor and heme oxygenase‐1 regulate the progression of colorectal liver metastases during hepatic ischemia‐reperfusion", Int J Cancer, 10 October 2020