News

Recent publication : Hepatocarcinoma Induces a Tumor Necrosis Factor-Dependent Kupffer Cell Death Pathway That Favors Its Proliferation Upon Partial Hepatectomy

Partial hepatectomy is one of the best treatment for Hepatocellular carcinoma. However, a significant amount of patients undergoes a recursion of the disease that could be accelerated by the surgery-associated inflammation. Using preclinical model, Jean-François Hastir, in the team of Véronique Flamand, brings new evidence on the link between hepatectomy-induced Kupffer cell death and local inflammation that contributes to tumor progression. He discovered that primary hepatocellular carcinoma induces the switch from the TNF-α-RIPK3-caspase8 dependent Kupffer cell apoptosis to a TNF-α-RIPK3-caspase1-dependent disappearance (i.e. pyroptosis) during partial hepatectomy. This pyroptosis allows the recruitment of monocyte-derived cells beneficial for the tumor and phenotypically different from Kupffer cells. The present work is offering new therapeutic targets for the surgery-based treatment of hepatocarcinoma.

Original research article : Hastir JF et al., "Hepatocarcinoma Induces a Tumor Necrosis Factor-Dependent Kupffer Cell Death Pathway That Favors Its Proliferation Upon Partial Hepatectomy", Front Oncol., 16 October 2020
December 01st 2020 - 07:45