New publication on the role of T follicular helper cells in breast cancer

In this article published in the Journal of Clinical Investigation, the group of Karen Willard-Gallo explores the mechanisms leading to the formation of active Tertiary Lymphoid Structures (TLS) in breast cancer. Analysis of active versus inactive TLS in untreated patients revealed that the former are associated with positive clinical outcomes. They explore the role of tumor-infiltrating Follicular Helper (Tfh) and Regulatory T cells (Tfr) in this process and show that these cells represent a potential key target of PD1/PDL1 blockade.