New publication on the Preventive impact of maternal probiotics administration on the development of neonatal Th-2 type allergic airways disease

Gut microbiota plays a role in the neonatal immune education and could influence susceptibility to Th2-type immune disorders, such as allergies, the most prevalent chronic diseases in early childhood. Justine Smout and the team of Véronique Flamand observed that probiotic supplementation to pregnant/breastfeeding mice prevents the development of allergic airways disease in their offspring. In this setting, she demonstrated that the Lactobacillus rhamnosus strain (Vésale Pharma) modulates the neonatal allergen-specific CD4 Helper T-cell activation.

Maternal Lactobacillus rhamnosus administration impacts neonatal CD4 T-cell activation and prevents murine T helper 2-type allergic airways disease.
Smout J, Valentin C, Delbauve S, Pauwels J, Köhler A, Flamand V., Front Immunol. 2023 Jan 4;13:1082648. doi: 10.3389/fimmu.2022.1082648. eCollection 2022.PMID: 36685549