New publication in Cancer Immunology Research : PHD2 Constrains Antitumor CD8 T-cell Activity

The successes of immunotherapy no longer need to be demonstrated. The identification of tumor antigens, the analysis of immune responses within tumors and the effect of checkpoint inhibitors demonstrate that the immune system is able to detect and control cancer cells in a proportion of patients. However, the tumor microenvironment is complex and can inhibit anti-tumor immune responses. This environment is characterized, among other things, by oxygen deprivation due to the presence of poorly functioning vessels.
The Immunobiology Laboratory (ULB Center for Research in Immunology) studied the effect of hypoxia on the immune response in two mouse tumor models. Surprisingly, the results show that stabilization of the HIF oxygen sensor in T lymphocytes (which mimics the effect of hypoxia) induces tumor rejection in 65% of mice and potentiates the cytotoxic response within the tumor. In addition, HIF stabilization works synergistically with checkpoint inhibition, an approach used clinically. Hypoxia can therefore have a beneficial effect on the anti-tumor response and represents a potential target in immunotherapy.

Original Article: PHD2 Constrains Antitumor CD8 T-cell Activity
Charlotte Bisilliat Donnet, Valérie Acolty, Abdulkader Azouz, Anaelle Taquin, Coralie Henin,
Sarah Trusso Cafarello, Sebastien Denanglaire, Massimiliano Mazzone, Guillaume Oldenhove,
Oberdan Leo, Stanislas Goriely, and Muriel Moser
Cancer Immunol Res. 2023 Mar 1;11(3):339-350. doi: 10.1158/2326-6066.CIR-22-0099.PMID: 36603132