News list

New publication: Tumorigenesis and inflammation

January 27th 2021 - 21:13
Tristetraprolin (TTP) is an RNA-binding protein that is known to play a critical role in the resolution of inflammation through the destabilisation of key cytokine transcripts, such as that encoding TNF. Furthermore, decreased expression or function of TTP is consistently observed in many human malignancies. Using loss or gain of function approaches, Assiya Assabban and her colleagues from the lab of Stan Goriely provide in vivo evidence that TTP controls key oncogenic events during skin tumorigenesis, such as the EGFR pathway. These data strongly support the notion that deregulation of...

Le système immunitaire face au virus SARS-CoV-2 : Seminaire

December 07th 2020 - 16:31
Jeudi 10 décembre à 14h

Leçon de clôture du Professeur Michel Goldman

Titulaire du cours d’immunologie médicale à l’Université libre de Bruxelles de 1995 à 2020


Recent publication : Hepatocarcinoma Induces a Tumor Necrosis Factor-Dependent Kupffer Cell Death Pathway That Favors Its Proliferation Upon Partial Hepatectomy

December 01st 2020 - 07:45
Partial hepatectomy is one of the best treatment for Hepatocellular carcinoma. However, a significant amount of patients undergoes a recursion of the disease that could be accelerated by the surgery-associated inflammation. Using preclinical model, Jean-François Hastir, in the team of Véronique Flamand, brings new evidence on the link between hepatectomy-induced Kupffer cell death and local inflammation that contributes to tumor progression. He discovered that primary hepatocellular carcinoma induces the switch from the TNF-α-RIPK3-caspase8 dependent Kupffer cell apoptosis to a...

Recent publication : Myeloid tumor necrosis factor and heme oxygenase-1 regulate the progression of colorectal liver metastases during hepatic ischemia-reperfusion

October 23rd 2020 - 13:46
Liver ischemia/reperfusion occurring during surgical procedures such as partial hepatectomy contributes to colorectal liver metastasis progression. Desislava Germanova in the team of Véronique Flamand demonstrated that in this setting the tumor progression is occuring despite the local production of TNF by resident macrophages (Kupffer cells). She shows that the liver ischemia/reperfusion induced a Kupffer cell number decrease most likely through pyroptosis that favors the recruitment of TNF producing protective monocytes. However, the anti-tumoral capacity of these myeloid cells is...

New publication: T cell dysfunction in cancer

October 13th 2020 - 16:58
CD8 + T cells within the tumor microenvironment are exposed to various signals that ultimately determine functional outcomes. In October issue of Immunity, the team of Ludovic Martinet from the Centre de physiopathologie de Toulouse Purpan (CPTP) identified a new mechanism involved in T cell dysfunction. Through complementary approaches, involving cancer patients’ samples and relevant mouse tumor models, Weulersse et al. reveal that CD8+ T cells in the tumor microenvironment lose expression of the activating receptor CD226 (DNAM-1) in a manner that is Eomes dependent. CD226 loss restrains...

Recent publication : The mononuclear phagocyte system contributes to fibrosis in posttransplant Obliterans Bronchiolitis

October 09th 2020 - 13:07
Lung transplantation currently represents the only curative treatment for patients suffering from end-stage respiratory failure. However, when compared to other solid-organ transplants, the prognosis after lung transplantation remains quite poor, with a median survival of less than 7 years. The main cause for this high mortality is a disease called Bronchiolitis Obliterans Syndrome (BOS), which manifests as a progressive and irreversible loss of respiratory function, mainly due to the obliteration of the small airways (“bronchioles”) caused by fibrosis. The myofibroblasts, considered as...

Public defense of thesis by Alexandra DREESMAN

August 31st 2020 - 14:16
In order to obtain the academic title of PhD in Medical Sciences, jointly supervised with the "Vrije Universiteit Brussel" (VUB),
Alexandra DREESMAN will publicly defend on Thursday September 3, 2020 at 6 p.m., a doctoral thesis entitled:
"Development and evaluation of new diagnostic markers of tuberculosis in children".
Address of the day: Auditoire Bremer (Build. B - B2.002), route de Lennik 808 - 1070 Brussels

Two upcoming thesis defenses...

August 24th 2020 - 14:56
Caroline La and Maria Pia Di Campli will both very soon publicly defend their thesis to obtain the academic title of PhD in Medical Sciences
  • Wednesday, September 9th, at 5:00 p.m. : Caroline will defend her doctoral thesis entitled "Etude des interactions entre la peau, les intestins et les articulations dans un contexte inflammatoire"
  • Thursday, September 10th, at 5:00 p.m. : Maria Pia will defend her doctoral thesis entitled "Deciphering the role of the mononuclear phagocyte system in post-transplant airway fibrosis"
Modalities of attendance by video-conference will be communicated soon (in...

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