News list

Recent publication : Myeloid tumor necrosis factor and heme oxygenase-1 regulate the progression of colorectal liver metastases during hepatic ischemia-reperfusion

October 23rd 2020 - 13:46
Liver ischemia/reperfusion occurring during surgical procedures such as partial hepatectomy contributes to colorectal liver metastasis progression. Desislava Germanova in the team of Véronique Flamand demonstrated that in this setting the tumor progression is occuring despite the local production of TNF by resident macrophages (Kupffer cells). She shows that the liver ischemia/reperfusion induced a Kupffer cell number decrease most likely through pyroptosis that favors the recruitment of TNF producing protective monocytes. However, the anti-tumoral capacity of these myeloid cells is...

New publication: T cell dysfunction in cancer

October 13th 2020 - 16:58
CD8 + T cells within the tumor microenvironment are exposed to various signals that ultimately determine functional outcomes. In October issue of Immunity, the team of Ludovic Martinet from the Centre de physiopathologie de Toulouse Purpan (CPTP) identified a new mechanism involved in T cell dysfunction. Through complementary approaches, involving cancer patients’ samples and relevant mouse tumor models, Weulersse et al. reveal that CD8+ T cells in the tumor microenvironment lose expression of the activating receptor CD226 (DNAM-1) in a manner that is Eomes dependent. CD226 loss restrains...

Recent publication : The mononuclear phagocyte system contributes to fibrosis in posttransplant Obliterans Bronchiolitis

October 09th 2020 - 13:07
Lung transplantation currently represents the only curative treatment for patients suffering from end-stage respiratory failure. However, when compared to other solid-organ transplants, the prognosis after lung transplantation remains quite poor, with a median survival of less than 7 years. The main cause for this high mortality is a disease called Bronchiolitis Obliterans Syndrome (BOS), which manifests as a progressive and irreversible loss of respiratory function, mainly due to the obliteration of the small airways (“bronchioles”) caused by fibrosis. The myofibroblasts, considered as...

Public defense of thesis by Alexandra DREESMAN

August 31st 2020 - 14:16
In order to obtain the academic title of PhD in Medical Sciences, jointly supervised with the "Vrije Universiteit Brussel" (VUB),
Alexandra DREESMAN will publicly defend on Thursday September 3, 2020 at 6 p.m., a doctoral thesis entitled:
"Development and evaluation of new diagnostic markers of tuberculosis in children".
Address of the day: Auditoire Bremer (Build. B - B2.002), route de Lennik 808 - 1070 Brussels

Two upcoming thesis defenses...

August 24th 2020 - 14:56
Caroline La and Maria Pia Di Campli will both very soon publicly defend their thesis to obtain the academic title of PhD in Medical Sciences
  • Wednesday, September 9th, at 5:00 p.m. : Caroline will defend her doctoral thesis entitled "Etude des interactions entre la peau, les intestins et les articulations dans un contexte inflammatoire"
  • Thursday, September 10th, at 5:00 p.m. : Maria Pia will defend her doctoral thesis entitled "Deciphering the role of the mononuclear phagocyte system in post-transplant airway fibrosis"
Modalities of attendance by video-conference will be communicated soon (in...

Valérie Wittamer Group is recruiting

August 24th 2020 - 13:56
Dr. Valérie Wittamer is looking for a Post-Doc to join her group ! 
Topic : Microglia functions in brain repair and regeneration using the zebrafish model

Follow this link for more information...

Job Offer at the Jules Bordet Institute

August 18th 2020 - 13:37
The Jules Bordet Insitute is looking for a PhD candidate !
Research project : immunotherapy and stereotatic irradiation in PDXS preclinical

Follow this link for more information... 

Collaboration between U-CRI and Dr. Das (University of Pittsburgh) for the analyses of high-dimensional immunological datasets

August 07th 2020 - 08:36
Recently, a collaborative research agreement was signed between U-CRI and the Center for Systems Immunology (CSI) at the University of Pittsburgh. This signing concretizes the continuation of a collaboration that began several years ago between Drs Arnaud Marchant and Jishnu Das.

Dr. Jishnu Das is Assistant Professor at the Departments of Immunology and Computational and Systems Biology and Core Faculty member at the CSI. He has strong expertise in computational systems analyses of immunological data and his research focuses on the development and use of novel machine learning and network...

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